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Modeling tuberculosis in areas of high HIV prevalence

Published: 03 December 2006 Publication History

Abstract

We describe a discrete event simulation model of tuberculosis (TB) and HIV disease, parameterized to describe the dual epidemics in Harare, Zimbabwe. TB and HIV are the leading causes of death from infectious disease among adults worldwide and the number of TB cases has risen significantly since the start of the HIV epidemic, particularly in Sub-Saharan Africa, where the HIV epidemic is most severe. There is a need to devise new strategies for TB control in countries with a high prevalence of HIV. This model has been designed to investigate strategies for reducing TB transmission by more efficient TB case detection. The model structure and its validation are discussed.

References

[1]
Action Aid International. 2005. The impact of "operation Murambatsvina / Restore Order" in Zimbabwe. Available at <http://www.kubatana.net>
[2]
Aparicio JP, Capurro AF, Castillo-Chavez C. 2000. Transmission and dynamics of tuberculosis on generalized households. Journal of Theoretical Biology 206(3): 327--341.
[3]
Barnett G, Grzybowski S, Styblo K. 1971. Present risk of developing active tuberculosis in Saskatchewan according to previous tuberculin and X-ray status. Bull IUATLD; 45: 51--74.
[4]
Blower S, Small P, Hopwell P. 1996. Control strategies for tuberculosis epidemics: new models for old problems. Science 273: 497--500.
[5]
Blower SM, Gerberding JL. 1998. Understanding, predicting and controlling the emergence of drug-resistant tuberculosis: a theoretical framework. Journal of Molecular Medicine 76(9): 624--636.
[6]
Comstock G. 1982. Epidemiology of tuberculosis. Am Rev Resp Dis 125: 8--16.
[7]
Coronado V, Beck-Sague C, Hutton M et al. 1993. Transmission of multidrug-resistant Mycobacterium Tuberculosis in persons with human immunodeficiency virus infection in an urban hospital: epidemiological and restriction fragment length polymorphism analysis. J Infect Dis 168: 1053--1055.
[8]
Corbett EL, Watt C, Walker N, Maher D, Williams BG, Raviglione MS, et al. 2003. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med 163: 1009--1021.
[9]
Corbett EL, Charalambous S, Moloi VM, Fielding K, Grant AD, Dye C, De Cock KM, Hayes RJ, Williams BG, Churchyard GJ, 2004. Human immunodeficiency virus and the prevalence of undiagnosed tuberculosis in African gold miners. American Journal of Respiratory and Critical Care Medicine, 170:673--679
[10]
Corbett EL, Bandason T, Dauya E, Makamure B, Cheung YB, Munyati S, Matambo R, Godfrey-Faussett P, Hayes R, Churchyard GJ, Mason PR, 2005. HIV infection and the duration and control of prevalent tuberculosis disease in Harare, Zimbabwe. TSRU Progress Report, pp 28--39.
[11]
Currie CSM, Williams BG, Cheng RCH, Dye C. 2003. Tuberculosis epidemics driven by HIV: is prevention better than cure? AIDS 17(17): 2501--2508
[12]
Currie CSM, Williams BG, Corbett EL. 2005. Assessing the Impact of HIV on the Annual Risk of TB Infection Using a Mathematical Model. Proc. TSRU.
[13]
Daley C, Small P, Schechter G et al. 1992. An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. N Engl J Med 326: 231--235.
[14]
Debanne SM, Bielefeld RA, Cauthen GM, Daniel TM, Rowland DY. 2000. Multivariate Markovian modeling of tuberculosis: Forecast for the United States. Emerging Infectious Diseases 6(2): 148--157.
[15]
Di Perri G, Gruciani M, Danzi M et al. 1989. Nosocomial epidemic of active tuberculosis among HIV-infected patients. Lancet 2: 1502--1504.
[16]
Dye C, Garnett GP, Sleeman A, Williams BG. 1998. Prospects for worldwide tuberculosis control under the WHO DOTS strategy. Lancet 352(9144): 1886--1891
[17]
Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC. 1999. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. Journal of the American Medical Association 282: 677--686.
[18]
Edlin B, Tokars J, Grieco M et al. 1992. An outbreak of multidrug-resistant tuberculosis among hospitalised patinets with the acquired immune deficiency syndrome. N Engl J Med 326: 1514--1521.
[19]
Ferebee S. 1970. Controlled chemoprophylaxis trials in tuberculosis a general review. Adv Tuberc Res 17: 28--106.
[20]
Horwitz O, Wilbek E, Erickson PA. 1969. Epidemiological basis of tuberculosis eradication. 10 longitudinal studies on the risk of tuberculosis in the general population of a low-prevalence area. Bull World Health Org 41: 95--113.
[21]
Krishnamurthy V, Nair S, Gothi G et al. 1976. Incidence of tuberculosis among newly infected populations and in relation to the duration of infected status. Indian J Tuberc 33: 1--3.
[22]
Krishnamurthy V, Chaudhuri K. 1990. Risk of pulmonary tuberculosis associated with exogenous reinfection and endogenous reactivation in a south Indian rural population - A mathematical estimate. Indian J Tuberc 37: 63--67.
[23]
Morgan D, Mahe C, Mayanja B, Whitworth JAG. 2002. Progression to symptomatic disease in people infected with HIV-1 in rural Uganda: prospective cohort study. British Medical Journal 324: 193--197
[24]
Murray CJL, Salomon JA. 1998a. Modeling the impact of global tuberculosis control strategies. Proceedings of the National Academy of Sciences of the United States of America 95(23): 13881--13886
[25]
Murray CJL, Salomon JA. 1998b. Expanding the WHO tuberculosis control strategy: rethinking the role of active case-finding. Int. J. Tuberc Lung Dis 2(9): S9--S15
[26]
Murray M. 2002. Determinants of cluster distribution in the molecular epidemiology of Tuberculosis. Proceedings of the National Academy of Sciences of the United States of America 99(3): 1538--1543.
[27]
Rieder H. L. 2003. Contacts of tuberculosis patients in high-incidence countries. International Journal of Tuberculosis and Lung Disease, 7, pp S333--S336.
[28]
Salomon, J. A. and C. L. Murray. 2001. Modeling HIV/AIDS epidemics in Sub-Saharan Africa using seroprevalence data from antenatal clinics. Bulletin of the World Health Organization, 79 pp 596--607.
[29]
Schulzer M, Fitzgerald J, Enarson D, Grzybowski S. 1992. An estimate of the future size of the tuberculosis problem in sub-Saharan Africa resulting from HIV infection. Tuberc Lung Dis 73: 52--8.
[30]
Song BJ, Castillo-Chavez C, Aparicio JP. 2002. Tuberculosis models with fast and slow dynamics: the role of close and casual contacts. Mathematical Biosciences 180: 187--205
[31]
Styblo K. 1986. Tuberculosis control and surveillance. In: Advances in Respiratory Medicine. Flenley D, Retly J (editors). Edinburgh: Churchill Livingstone; pp77--108.
[32]
Styblo K. 1991. Epidemiology of Tuberculosis. The Hague: Royal Netherlands Tuberculosis Association (KNCV).
[33]
Sutherland I, Svandova E, Radhakrishna S. 1947. The development of clinical tuberculosis following infection with tubercle bacilli. Tubercle 28: 85.
[34]
Sutherland I. 1968. The ten-year incidence of clinical tuberculosis following 'conversion' in 2,550 individuals aged 14--19 years. Tuberculosis Surveillance and Research Unit Progress Report. The Hague, Royal Netherlands Tuberculosis Association (KNCV).
[35]
Vynnycky E. 1996. An investigation of the transmission dynamics of M. tuberculosis. PhD Thesis, University of London.
[36]
Vynnycky E, Fine PEM. 1997. The natural history of tuberculosis: the implications of age-dependent risks of disease and the role of reinfection. Epidemiol Infect 119: 183--201.
[37]
Williams BG, Granich R, Chauhan LS, Dharmshaktu NS, Dye C. 2005. The impact of HIV/AIDS on the control of tuberculosis in India. Proceedings of the National Academy of Sciences of the United States of America 102(27): 9619--9624.
[38]
World Health Organization. 1990. Acquired immunodeficiency syndrome (AIDS). Interim proposal for a WHO staging system for HIV infection and disease. Weekly Epidemiological Record 65: 221--224
[39]
World Health Organization. 1999. World Health Report, Geneva.
[40]
World Health Organization. 2003. Global tuberculosis control: surveillance, planning, financing. WHO/TB/2003.316, Geneva.
[41]
World Health Organization. 2006. Global tuberculosis control: surveillance, planning, financing. WHO/HTM/TB/2006.362, Geneva.

Cited By

View all
  • (2013)An agent-based simulation of a tuberculosis epidemicProceedings of the 2013 Winter Simulation Conference: Simulation: Making Decisions in a Complex World10.5555/2675983.2676261(2227-2238)Online publication date: 8-Dec-2013
  • (2007)Targeted strategies for tuberculosis in areas of high HIV prevalenceProceedings of the 39th conference on Winter simulation: 40 years! The best is yet to come10.5555/1351542.1351806(1487-1493)Online publication date: 9-Dec-2007

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cover image ACM Conferences
WSC '06: Proceedings of the 38th conference on Winter simulation
December 2006
2429 pages
ISBN:1424405017

Sponsors

  • IIE: Institute of Industrial Engineers
  • ASA: American Statistical Association
  • IEICE ESS: Institute of Electronics, Information and Communication Engineers, Engineering Sciences Society
  • IEEE-CS\DATC: The IEEE Computer Society
  • SIGSIM: ACM Special Interest Group on Simulation and Modeling
  • NIST: National Institute of Standards and Technology
  • (SCS): The Society for Modeling and Simulation International
  • INFORMS-CS: Institute for Operations Research and the Management Sciences-College on Simulation

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Winter Simulation Conference

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Published: 03 December 2006

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WSC06
Sponsor:
  • IIE
  • ASA
  • IEICE ESS
  • IEEE-CS\DATC
  • SIGSIM
  • NIST
  • (SCS)
  • INFORMS-CS
WSC06: Winter Simulation Conference 2006
December 3 - 6, 2006
California, Monterey

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WSC '06 Paper Acceptance Rate 177 of 252 submissions, 70%;
Overall Acceptance Rate 3,413 of 5,075 submissions, 67%

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Cited By

View all
  • (2013)An agent-based simulation of a tuberculosis epidemicProceedings of the 2013 Winter Simulation Conference: Simulation: Making Decisions in a Complex World10.5555/2675983.2676261(2227-2238)Online publication date: 8-Dec-2013
  • (2007)Targeted strategies for tuberculosis in areas of high HIV prevalenceProceedings of the 39th conference on Winter simulation: 40 years! The best is yet to come10.5555/1351542.1351806(1487-1493)Online publication date: 9-Dec-2007

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