skip to main content
10.5555/1218112.1218412acmconferencesArticle/Chapter ViewAbstractPublication PageswscConference Proceedingsconference-collections
Article

Modeling and analysis of biological processes by mem(brane) calculi and systems

Published: 03 December 2006 Publication History

Abstract

In recent years, the modeling and analysis techniques developed in the area of formal languages and of concurrent process calculi have been successfully applied to the field of Systems Biology. In this setting, Brane Calculi and Membrane Systems are two of the most prominent approaches for the modeling of the behaviour of biological membranes. Membrane Systems have been introduced by Gh. Paun as a class of distributed parallel computing devices of a biochemical type, while Brane Calculi are a family of process calculi, based on a set of biologically inspired primitives of membrane interaction. In this paper we model the behaviour of a biological process - namely, the LDL Cholesterol Degradation Pathway - in both Brane Calculi and Membrane Systems. We also provide a brief discussion on the application of analysis techniques to this case study.

References

[1]
Ardelean, I. I., and D. Besozzi. 2005. On modelling ion fluxes across biological membranes with P systems. In Proceedings of the Third Brainstorming Week on Membrane Computing, Sevilla (Spain), 35--42.
[2]
Busi, N. 2006. Deciding behavioural properties in Brane Calculi. In Proceedings Computational Methods in System Biology 2006 (CMSB 2006), to appear.
[3]
Busi, N., M. Gabbrielli and G. Zavattaro. 2003. Replication vs. recursive definitions in channel based calculi. In Proceedings of 30th International Colloquium on Automata, Languages and Programming (ICALP'03), LNCS 2719, 133--144, Springer-Verlag.
[4]
Busi, N., and R. Gorrieri. 2006. On the computational power of Brane Calculi. Transactions on Computational Systems Biology, LNCS, Springer, to appear.
[5]
Cardelli, L. 2004. L. Cardelli. Brane Calculi - Interactions of biological membranes. In Proceedings Computational Methods in System Biology 2004 (CMSB 2004), LNCS 3082, Springer, 2005.
[6]
Ciobanu, G., Gh. Pǎun and M. J. Perez-Jimenez, eds. 2005. Applications of membrane computing. Springer-Verlag, Berlin, 43--80.
[7]
Finkel, A. and Ph. Schnoebelen. 2001. Well-structured transition systems everywhere! Theoretical Computer Science, 256:63--92, Elsevier.
[8]
Lodish, H., A. Berk, P. Matsudaira, C. A. Kaiser, M. Krieger, M. P. Scott, S. L. Zipursky and J. Darnell. 1999. Molecular cell biology. W. H. Freeman and Company, 4th edition.
[9]
Milner, R. 1989. Communication and concurrency. Prentice-Hall.
[10]
Milner, R., J. Parrow and D. Walker, 1992. A calculus of mobile processes. Journal of Information and Computation, 100:1--77. Academic Press.
[11]
Pǎun, G. 2002. Membrane computing. An introduction. Springer.
[12]
Pǎun, G. 2000. Computing with membranes. Journal of Computer and System Sciences, 61(1): 108--143.
[13]
Pescini, D., D. Besozzi and G. Mauri. 2005. Investigating local evolutions in dynamical probabilistic P systems in G. Ciobanu, Gh. Pǎun, Pre-Proceedings of First International Workshop on Theory and Application of P Systems, Timisoara, Romania, 83--90
[14]
Pilegaard, H., F. Nielsen and H. Riis Nielson. 2005. Static analysis of a model of the LDL degradation pathway. in Proceedings Computational Methods in System Biology 2005 (CMSB 2005).
[15]
Regev, A., E. M. Panina, W. Silverman, L. Cardelli and E. Shapiro. 2004. BioAmbients: an abstraction for biological compartments. Theoretical Computer Science, 325(1): 141--167, Elsevier.

Cited By

View all
  • (2015)A Global Occurrence Counting Analysis for Brane CalculiRevised Selected Papers of the 25th International Symposium on Logic-Based Program Synthesis and Transformation - Volume 952710.1007/978-3-319-27436-2_11(179-200)Online publication date: 13-Jul-2015
  • (2008)Process algebras in systems biologyProceedings of the Formal methods for the design of computer, communication, and software systems 8th international conference on Formal methods for computational systems biology10.5555/1786698.1786707(265-312)Online publication date: 2-Jun-2008
  • (2006)Deciding behavioural properties in brane calculiProceedings of the 2006 international conference on Computational Methods in Systems Biology10.1007/11885191_2(17-31)Online publication date: 18-Oct-2006

Recommendations

Comments

Information & Contributors

Information

Published In

cover image ACM Conferences
WSC '06: Proceedings of the 38th conference on Winter simulation
December 2006
2429 pages
ISBN:1424405017

Sponsors

  • IIE: Institute of Industrial Engineers
  • ASA: American Statistical Association
  • IEICE ESS: Institute of Electronics, Information and Communication Engineers, Engineering Sciences Society
  • IEEE-CS\DATC: The IEEE Computer Society
  • SIGSIM: ACM Special Interest Group on Simulation and Modeling
  • NIST: National Institute of Standards and Technology
  • (SCS): The Society for Modeling and Simulation International
  • INFORMS-CS: Institute for Operations Research and the Management Sciences-College on Simulation

Publisher

Winter Simulation Conference

Publication History

Published: 03 December 2006

Check for updates

Qualifiers

  • Article

Conference

WSC06
Sponsor:
  • IIE
  • ASA
  • IEICE ESS
  • IEEE-CS\DATC
  • SIGSIM
  • NIST
  • (SCS)
  • INFORMS-CS
WSC06: Winter Simulation Conference 2006
December 3 - 6, 2006
California, Monterey

Acceptance Rates

WSC '06 Paper Acceptance Rate 177 of 252 submissions, 70%;
Overall Acceptance Rate 3,413 of 5,075 submissions, 67%

Contributors

Other Metrics

Bibliometrics & Citations

Bibliometrics

Article Metrics

  • Downloads (Last 12 months)1
  • Downloads (Last 6 weeks)0
Reflects downloads up to 07 Mar 2025

Other Metrics

Citations

Cited By

View all
  • (2015)A Global Occurrence Counting Analysis for Brane CalculiRevised Selected Papers of the 25th International Symposium on Logic-Based Program Synthesis and Transformation - Volume 952710.1007/978-3-319-27436-2_11(179-200)Online publication date: 13-Jul-2015
  • (2008)Process algebras in systems biologyProceedings of the Formal methods for the design of computer, communication, and software systems 8th international conference on Formal methods for computational systems biology10.5555/1786698.1786707(265-312)Online publication date: 2-Jun-2008
  • (2006)Deciding behavioural properties in brane calculiProceedings of the 2006 international conference on Computational Methods in Systems Biology10.1007/11885191_2(17-31)Online publication date: 18-Oct-2006

View Options

Login options

View options

PDF

View or Download as a PDF file.

PDF

eReader

View online with eReader.

eReader

Figures

Tables

Media

Share

Share

Share this Publication link

Share on social media