Think simulation - think experiment: the virtual cell paradigm
Pages 1713 - 1719
Abstract
The Virtual Cell modeling and simulation framework is the product of interdisciplinary research in biology that applies the diverse strengths and experiences of individuals from engineering, the physical sciences, the biological sciences, and mathematics. A key feature is the separation of layers (core technologies and abstractions) representing biological models, physical mechanisms, geometry, mathematical models and numerical methods. This reduces software complexity, allowing independent development and verification, but most importantly it clarifies the impact of modeling decisions, assumptions, and approximations. The result is a physically consistent, mathematically rigorous, spatial modeling and simulation framework for cell biology. The Virtual Cell has a rich, interactive user interface which connects to remote services providing scalable access to a modeling database and a large dedicated cluster for shared computation and storage. In addition to new modeling capabilities, future developments will emphasize data and tool interoperability, extensibility, and experimentally oriented model analysis tools.
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- Think simulation - think experiment: the virtual cell paradigm
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Published In
December 2006
2429 pages
ISBN:1424405017
- Editors:
- L. Felipe Perrone,
- Barry G. Lawson,
- Jason Liu,
- Frederick P. Wieland,
- General Chair:
- David Nicol,
- Program Chair:
- Richard Fujimoto
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- IIE: Institute of Industrial Engineers
- ASA: American Statistical Association
- IEICE ESS: Institute of Electronics, Information and Communication Engineers, Engineering Sciences Society
- IEEE-CS\DATC: The IEEE Computer Society
- SIGSIM: ACM Special Interest Group on Simulation and Modeling
- NIST: National Institute of Standards and Technology
- (SCS): The Society for Modeling and Simulation International
- INFORMS-CS: Institute for Operations Research and the Management Sciences-College on Simulation
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Winter Simulation Conference
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Published: 03 December 2006
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- IIE
- ASA
- IEICE ESS
- IEEE-CS\DATC
- SIGSIM
- NIST
- (SCS)
- INFORMS-CS
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WSC '06 Paper Acceptance Rate 177 of 252 submissions, 70%;
Overall Acceptance Rate 3,413 of 5,075 submissions, 67%
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