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Discrete event simulation for batch processing

Published: 03 December 2006 Publication History

Abstract

This paper presents the modeling of batch processes using discrete event simulation. Discrete event simulation is often used for transactional-based processes; however, this paper describes an example of representing each batch as a single transaction in order to model process cycle time and utility usage. An example is provided to demonstrate the use of this method for simulating water-for-injection usage in a biopharmaceutical process.

References

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Ball, P. 2001. Introduction to discrete event simulation. Originally presented at the 2nd DYCOMANS workshop on Management and Control: Tools in Action, Algarve, Portugal, 15--17 May 1996, 367--376. <http://www.dmem.strath.ac.uk/~pball/simulation/simulate.html>. {accessed March 13, 2006}
[2]
Banks, J., J. S. Carson II, B. L. Nelson, and D. M. Nicol. 2005. Discrete-Event System Simulation. 4th ed. Upper Saddle River, New Jersey: Pearson Prentice Hall.
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Domanski, B. 1999. Simulation versus analytic modeling in large computing environments. White paper, Responsive Systems Company. <http://www.responsivesystems.com/papers/misc/Simulation.pdf>. {accessed March 13, 2006}
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Hoerl, R. and R. D. Snee. 2002. Statistical Thinking: Improving Business Performance. Pacific Grove, California: Duxbury.
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Hwang, F. 1997. Batch pharmaceutical process design via simulation. Pharmaceutical Engineering, January/February. <http://www.ispe.org//Template.cfm? Section=Referece&Template=/MembersOnly.cfm&ContentID=13019&CFID=2610699&CFTOKEN=46656408>&ContentID=13019&CFID=2610699&CFTOKEN=46656408>&CFID=2610699&CFTOKEN=46656408>&CFTOKEN=46656408>>. {accessed March 13, 2006}
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Micrografx. 2001. The role of process modeling and management within six sigma. White paper. Dallas, Texas. <http://courses.washington.edu/outfox/IgrafxProcessMgtandSix%20Sigma.pdf>. {accessed March 13, 2006}
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Park, S., and L. Leemis. Discrete-event simulation: A first course. Presentation, College of William and Mary. <http://www.cs.wm.edu/~esmirni/Teaching/cs526/DESAFC-1.1.ppt>. {accessed March 13, 2006}
[8]
Schriber, T. J., and Brunner, D. T., Inside discrete-event simulation software: How it works and why it matters. In Proceedings of the 2005 Winter Simulation Conference, ed. M. E. Kuhl, N. M. Steiger, F. B. Armstrong, and J. A. Joines, 167--177. Piscataway, New Jersey: Institute of Electrical and Electronics Engineers.
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Six Sigma Academy. 2002. The Black Belt Memory Jogger. 1st ed. Salem, New Hampshire: GOAL/QPC.
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Watson, G. 2004. Simulation Analysis. Monsanto Six Sigma Black Belt Training 2004, St. Louis. Business Systems Solutions International, Inc.

Cited By

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  • (2015)A modular approach for modeling active pharmaceutical ingredient manufacturing plantProceedings of the 2015 Winter Simulation Conference10.5555/2888619.2888877(2260-2271)Online publication date: 6-Dec-2015
  • (2013)Bottleneck analysis in a pharmaceutical production line using simulation approachProceedings of the 2013 Summer Computer Simulation Conference10.5555/2557696.2557711(1-8)Online publication date: 7-Jul-2013
  • (2011)Nonlinear optimization to generate non-overlapping random dot patternsProceedings of the Winter Simulation Conference10.5555/2431518.2431807(2419-2430)Online publication date: 11-Dec-2011
  • Show More Cited By

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Published In

cover image ACM Conferences
WSC '06: Proceedings of the 38th conference on Winter simulation
December 2006
2429 pages
ISBN:1424405017

Sponsors

  • IIE: Institute of Industrial Engineers
  • ASA: American Statistical Association
  • IEICE ESS: Institute of Electronics, Information and Communication Engineers, Engineering Sciences Society
  • IEEE-CS\DATC: The IEEE Computer Society
  • SIGSIM: ACM Special Interest Group on Simulation and Modeling
  • NIST: National Institute of Standards and Technology
  • (SCS): The Society for Modeling and Simulation International
  • INFORMS-CS: Institute for Operations Research and the Management Sciences-College on Simulation

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Winter Simulation Conference

Publication History

Published: 03 December 2006

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WSC06
Sponsor:
  • IIE
  • ASA
  • IEICE ESS
  • IEEE-CS\DATC
  • SIGSIM
  • NIST
  • (SCS)
  • INFORMS-CS
WSC06: Winter Simulation Conference 2006
December 3 - 6, 2006
California, Monterey

Acceptance Rates

WSC '06 Paper Acceptance Rate 177 of 252 submissions, 70%;
Overall Acceptance Rate 3,413 of 5,075 submissions, 67%

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Cited By

View all
  • (2015)A modular approach for modeling active pharmaceutical ingredient manufacturing plantProceedings of the 2015 Winter Simulation Conference10.5555/2888619.2888877(2260-2271)Online publication date: 6-Dec-2015
  • (2013)Bottleneck analysis in a pharmaceutical production line using simulation approachProceedings of the 2013 Summer Computer Simulation Conference10.5555/2557696.2557711(1-8)Online publication date: 7-Jul-2013
  • (2011)Nonlinear optimization to generate non-overlapping random dot patternsProceedings of the Winter Simulation Conference10.5555/2431518.2431807(2419-2430)Online publication date: 11-Dec-2011
  • (2007)Monte Carlo simulation to propose improvements of an alkyd resin processProceedings of the 7th WSEAS International Conference on Simulation, Modelling and Optimization10.5555/1353862.1353945(469-473)Online publication date: 15-Sep-2007

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