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A high-performance droplet router for digital microfluidic biochips

Published: 13 April 2008 Publication History

Abstract

In this paper, we propose a high-performance droplet router for digital microfluidic biochip (DMFB) design. Due to recent advancements in bio-MEMS, the design complexity and the scale of a DMFB are expected to explode in near future, thus requiring strong support from CAD as in conventional VLSI design. Among multiple design stages of a DMFB, droplet routing which schedules the movement of each droplet in a time-multiplexed manner is a critical challenge due to high complexity as well as large impacts on performance. Our algorithm first routes a droplet with higher bypassibility which less likely blocks the movement of the others. When multiple droplets form a deadlock, our algorithm resolves it by backing off some droplets for concession. A final compaction step further enhances timing as well as fault-tolerance by tuning each droplet movement greedily. Experimental results on hard benchmarks show that our algorithm achieves over 35x and 20x better routability with comparable timing and fault-tolerance than the popular prioritized A* search [2] and the state-of-the-art network-flow based algorithm [18], respectively

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Cited By

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  • (2023)Automated path selection technique while incorporating multiple assay operations and cross-contamination avoidance in cross-referencing DMFBsIntegration, the VLSI Journal10.1016/j.vlsi.2022.09.01388:C(125-138)Online publication date: 1-Jan-2023
  • (2021)Droplet Transportation in MEDA-Based Biochips: An Enhanced Technique for Intelligent Cross-Contamination AvoidanceIEEE Transactions on Very Large Scale Integration (VLSI) Systems10.1109/TVLSI.2021.307141029:7(1451-1464)Online publication date: Jul-2021
  • (2017)Dynamic washout multiple droplet lab on chip routing: Dynamic washing technique2017 Fourth International Conference on Signal Processing, Communication and Networking (ICSCN)10.1109/ICSCN.2017.8085706(1-6)Online publication date: Mar-2017
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    cover image ACM Conferences
    ISPD '08: Proceedings of the 2008 international symposium on Physical design
    April 2008
    218 pages
    ISBN:9781605580487
    DOI:10.1145/1353629
    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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    Published: 13 April 2008

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    Author Tags

    1. biochip
    2. microfluidics
    3. routing
    4. synthesis

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    April 13 - 16, 2008
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    Cited By

    View all
    • (2023)Automated path selection technique while incorporating multiple assay operations and cross-contamination avoidance in cross-referencing DMFBsIntegration, the VLSI Journal10.1016/j.vlsi.2022.09.01388:C(125-138)Online publication date: 1-Jan-2023
    • (2021)Droplet Transportation in MEDA-Based Biochips: An Enhanced Technique for Intelligent Cross-Contamination AvoidanceIEEE Transactions on Very Large Scale Integration (VLSI) Systems10.1109/TVLSI.2021.307141029:7(1451-1464)Online publication date: Jul-2021
    • (2017)Dynamic washout multiple droplet lab on chip routing: Dynamic washing technique2017 Fourth International Conference on Signal Processing, Communication and Networking (ICSCN)10.1109/ICSCN.2017.8085706(1-6)Online publication date: Mar-2017
    • (2016)Routing-Based CompilationFault-Tolerant Digital Microfluidic Biochips10.1007/978-3-319-23072-6_9(115-133)Online publication date: 2016
    • (2016)Design Methodology for Digital Microfluidic BiochipsFault-Tolerant Digital Microfluidic Biochips10.1007/978-3-319-23072-6_2(13-28)Online publication date: 2016
    • (2015)SVM-Based Routability-Driven Chip-Level Design for Voltage-Aware Pin-Constrained EWOD ChipsProceedings of the 2015 Symposium on International Symposium on Physical Design10.1145/2717764.2717777(49-56)Online publication date: 29-Mar-2015
    • (2014)Practical Functional and Washing Droplet Routing for Cross-Contamination Avoidance in Digital Microfluidic BiochipsProceedings of the 51st Annual Design Automation Conference10.1145/2593069.2593189(1-6)Online publication date: 1-Jun-2014
    • (2014)Physical-Level Synthesis for Digital Lab-On-a-Chip Considering Variation, Contamination, and DefectIEEE Transactions on NanoBioscience10.1109/TNB.2013.229494313:1(3-11)Online publication date: Mar-2014
    • (2012)Error-Tolerant Digital Microfluidic Lab-on-ChipHandbook of Nanoscience, Engineering, and Technology, Third Edition10.1201/b11930-34(867-892)Online publication date: 9-Apr-2012
    • (2012)Optimization techniques for the synchronization of concurrent fluidic operations in pin-constrained digital microfluidic biochipsIEEE Transactions on Very Large Scale Integration (VLSI) Systems10.1109/TVLSI.2011.214539720:6(1132-1145)Online publication date: 1-Jun-2012
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