skip to main content
10.1145/2110363.2110413acmconferencesArticle/Chapter ViewAbstractPublication PagesihiConference Proceedingsconference-collections
research-article

Comparing drug-class membership in ATC and NDF-RT

Published: 28 January 2012 Publication History

Abstract

The Anatomical Therapeutic Chemical (ATC) classification system is widely used in Europe for the classification and coding of drugs. However, ATC is not well integrated with other medication terminologies (e.g., NDF-RT -- the National Drug File-Reference Terminology), which hinders the integration of data coded to these two systems. In this work, we propose to map ATC to NDF-RT, via the Unified Medical Language System (UMLS), in which several medication terminologies are integrated, including NDF-RT but not ATC. Only half of ATC terms were successfully mapped to the UMLS using automatic lexical techniques, resulting in very few overlapping drug-class pairs between ATC and NDF-RT. To improve these results, we performed a manual mapping of cardiovascular ATC and NDF-RT classes, which increased the number of common drug-class pairs from 39 to 128. We believe that the discovery of mappings between ATC and NDF-RT classes could be further automated and made more effective by identifying mappings between the drugs in these classes.

References

[1]
Aronson, A. R. and Lang, F.-M. 2010. An overview of MetaMap: historical perspective and recent advances. Journal of the American Medical Informatics Association: JAMIA. 17, 3 (may. 2010), 229--236.
[2]
Bodenreider, O. 2004. The Unified Medical Language System (UMLS): integrating biomedical terminology. Nucleic Acids Research. 32, Database issue (jan. 2004), D267--270.
[3]
Bodenreider, O. and McCray, A. T. 2003. Exploring semantic groups through visual approaches. Journal of Biomedical Informatics. 36, 6 (dec. 2003), 414--432.
[4]
Bodenreider, O., Mougin, F., and Burgun, A. 2010. Automatic determination of anticoagulation status with NDF-RT. Proceedings of the 13th ISMB'2010 SIG meeting Bio-ontologies (2010), 140--143.
[5]
Coloma, P. M. et al. 2011. Combining electronic healthcare databases in Europe to allow for large-scale drug safety monitoring: the EU-ADR Project. Pharmacoepidemiology and Drug Safety. 20, 1 (jan. 2011), 1--11.
[6]
DebugIT: 2011. http://www.debugit.eu/.
[7]
Guidelines for ATC classification and DDD assignment, Oslo: 2010. http://www.whocc.no/filearchive/publications/2011guidelines.pdf.
[8]
Hole, W. T. and Srinivasan, S. 2000. Discovering missed synonymy in a large concept-oriented Metathesaurus. Proceedings of the AMIA Annual Symposium (2000), 354--358.
[9]
Klein, T. E. et al. 2001. Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. The Pharmacogenomics Journal. 1, 3 (2001), 167--170.
[10]
Knox, C. et al. 2011. DrugBank 3.0: a comprehensive resource for omics research on drugs. Nucleic Acids Research. 39, Database issue (jan. 2011), D1035--1041.
[11]
Lincoln, M. J. et al. 2004. U.S. Department of Veterans Affairs Enterprise Reference Terminology strategic overview. Studies in Health Technology and Informatics. 107, Pt 1 (2004), 391--395.
[12]
McCray, A. T., Srinivasan, S., and Browne, A. C. 1994. Lexical methods for managing variation in biomedical terminologies. Proceedings of the AMIA Annual Symposium (1994), 235--239.
[13]
Mortensen, J. and Bodenreider, O. 2010. Evaluating pharmacologic classes in NDF-RT. Proceedings of the Fourth International Symposium on Semantic Mining in Biomedicine (2010), 119--124.
[14]
NLM. NDF-RT API: 2011. http://rxnav.nlm.nih.gov/NdfrtAPI.html.
[15]
NLM. RxNorm API: 2011. http://rxnav.nlm.nih.gov/RxNormAPI.html.
[16]
Senger, C. et al. 2011. Design and evaluation of an ontology-based drug application database. Methods of Information in Medicine. 50, 3 (may 2011), 273--284.
[17]
Sun, Y. 2004. Methods for automated concept mapping between medical databases. Journal of Biomedical Informatics. 37, 3 (jun. 2004), 162--178.
[18]
Wishart, D. S. et al. 2008. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Research. 36, Database issue (jan. 2008), D901--906.

Cited By

View all
  • (2024)A Comprehensive Survey of Studies on Predicting Anatomical Therapeutic Chemical Classes of DrugsACM Computing Surveys10.1145/369971357:3(1-31)Online publication date: 11-Nov-2024
  • (2020)UMLS at 30 years: How it is used and published (Preprint)JMIR Medical Informatics10.2196/20675Online publication date: 25-May-2020
  • (2016)Evaluating NDF-RT’s Comprehensiveness as a Drugs Classification Standard: Drug Interaction CheckerContemporary Consumer Health Informatics10.1007/978-3-319-25973-4_9(169-198)Online publication date: 22-Mar-2016
  • Show More Cited By

Recommendations

Comments

Information & Contributors

Information

Published In

cover image ACM Conferences
IHI '12: Proceedings of the 2nd ACM SIGHIT International Health Informatics Symposium
January 2012
914 pages
ISBN:9781450307819
DOI:10.1145/2110363
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

Sponsors

Publisher

Association for Computing Machinery

New York, NY, United States

Publication History

Published: 28 January 2012

Permissions

Request permissions for this article.

Check for updates

Author Tags

  1. atc
  2. coding of drugs
  3. data integration
  4. mapping of terminologies
  5. ndf-rt
  6. umls

Qualifiers

  • Research-article

Conference

IHI '12
Sponsor:
IHI '12: ACM International Health Informatics Symposium
January 28 - 30, 2012
Florida, Miami, USA

Contributors

Other Metrics

Bibliometrics & Citations

Bibliometrics

Article Metrics

  • Downloads (Last 12 months)4
  • Downloads (Last 6 weeks)3
Reflects downloads up to 20 Feb 2025

Other Metrics

Citations

Cited By

View all
  • (2024)A Comprehensive Survey of Studies on Predicting Anatomical Therapeutic Chemical Classes of DrugsACM Computing Surveys10.1145/369971357:3(1-31)Online publication date: 11-Nov-2024
  • (2020)UMLS at 30 years: How it is used and published (Preprint)JMIR Medical Informatics10.2196/20675Online publication date: 25-May-2020
  • (2016)Evaluating NDF-RT’s Comprehensiveness as a Drugs Classification Standard: Drug Interaction CheckerContemporary Consumer Health Informatics10.1007/978-3-319-25973-4_9(169-198)Online publication date: 22-Mar-2016
  • (2014)Pharmacological class data representation in the Web Ontology Language (OWL)2014 IEEE International Conference on Big Data (Big Data)10.1109/BigData.2014.7004397(77-84)Online publication date: Oct-2014

View Options

Login options

View options

PDF

View or Download as a PDF file.

PDF

eReader

View online with eReader.

eReader

Figures

Tables

Media

Share

Share

Share this Publication link

Share on social media