ABSTRACT
The past decade has seen a revolution in genomic technologies that enable a flood of genome-wide profiling of many molecular elements on human genomes. This massive-scale "-omics" data provides researchers with an unprecedented opportunity to understand gene regulation that can enable new insights into principles of life, the study of diseases, and the development of treatments and drugs. Computational challenges are the major bottlenecks for comprehensive genome-wide data analysis of gene regulation. Such data sets are complex, structured and at an unprecedented scale of data growth. Problems of this nature may be particularly well suited to deep learning techniques that recently show impressive results across a variety of domains. This tutorial aims to provide an extensive literature review about the state-of-the-art techniques in deep Learning, to examine how deep learning is enabling changes at analyzing datasets about gene regulations, and to foresee the potential of deep learning to transform several areas of biology and medicine.
Index Terms
- ACM-BCB'18 Tutorial: Making Deep Learning Understandable for Analyzing Sequential Data about Gene Regulation
Recommendations
Inclusion of Textual Documentation in the Analysis of Multidimensional Data Sets: Application to Gene Expression Data
Recently, biology has been confronted with large multidimensional gene expression data sets where the expression of thousands of genes is measured over dozens of conditions. The patterns in gene expression are frequently explained retrospectively by ...
Gene function classification using NCI-60 cell line gene expression profiles
Gene expression patterns from NCI's panel of 60 cell lines were used to train a Neural Network model for classifying genes to pathways. The model assigns probabilities to each gene for each of the 21 modeled pathways assigned by the Kyoto Encyclopedia ...
Time-frequency feature detection for time-course microarray data
SAC '04: Proceedings of the 2004 ACM symposium on Applied computingGene clustering based on microarray data provides useful functional information to the working biologists. Many current gene-clustering algorithms rely on Euclidean-based distance metrics and fail to capture the time-dependent features of the data, ...
Comments